In human gastric cancer, Sulf-1 was reported to inhibit hedgehog signaling involved in Epithelial Mesenchymal transition (EMT) and at the same time it down regulated metastasis associated genes such as GLI1, PTCH1/2, HHIP, c-myc, CCND1, FOXM1 and bcl2 [14]. Here, SULF1 is linked to gastric cancer.