Furthermore, Msln stimulated PI3/Akt and MAPK/ERK signaling and inhibits pro-apoptotic factors such as Bad and Bax and causes the tumor cells to survive for longer periods, and at the same time promotes the expression of anti-apoptotic gene such as Bcl-2 and Mcl-1 [28, 29]. The gene discussed is BCL2; the disease is neoplasm.