The silencing of DUSP22 in PTCL with 6p25.3 rearrangements [12] pointed out this gene as a candidate tumor suppressor whose inactivation may contribute to the pathogenesis of PTCL subtypes, notably ALCL (essentially cutaneous) and T-MF [9, 10, 11, 12, 13, 14]. This evidence concerns the gene DUSP22 and mature T-cell and NK-cell non-Hodgkin lymphoma.