The TMPRSS2-ERG gene fusion signature identified by comparing PCa patients with and without the fusion [31] was significantly enriched in the ERG subnetworks (Figures 2A and 2B, Fisher's exact test p= 1 × 10−9 and 7 × 10−5 for TCGA and Taylor, respectively). Here, TMPRSS2 is linked to posterior cortical atrophy.