LASP1 and colorectal carcinoma: In conclusion, by finding a novel target, LASP1, in the suppression of miR-145 on CRC invasion and metastasis and observing a novel mechanism, the cooperation between histone methylation and transcription factors, in the regulation of miR-145 during CRC carcinogenesis, we provided an insight into the regulatory network in CRC cells and offered new targets for treating CRC patients.