LASP1 and colorectal carcinoma: Importantly, we are the first to demonstrate that miR-145 directly suppresses LASP1 to inhibit the invasion and metastasis of CRC and also the first to find that a histone methylation involved mechanism, together with the binding of transcription factors on the promoter region of miR-145, may co-regulate the expression of miR-145 in CRC cells.