Sample RD_001_C1 has a germline mutation in BRCA1 (S1655fs*16) at 49% frequency (in 80% tumor) in the NGS data and hemizygous deletion (i.e. LOH) in BRCA1, suggesting the mutant allele is present in a hemizygous state in the tumor and driver of disease. Here, BRCA1 is linked to neoplasm.