SPOCK1 expression was observed in 18.8% (90/478) of IDC specimens, and the expression was positively correlated with a high pathological tumor size (P = 0.012), a high histological grade (P = 0.013), the triple-negative phenotype (ER−, PR−, and HER2−; P = 0.022), and the basal-like phenotype (ER−, PR−, HER2− and CK5/6+; P = 0.026). The gene discussed is KRT5; the disease is neoplasm.