By inhibition of BACE1-mediated cleavage of APP, quercetin suppresses β-amyloid synthesis in cell-free, cell-based and in silico studies [23].Using primary Tg2576 AD mouse neurons, quercetin metabolite quercetin-3-O-glucuronide has been proved to significantly reduce the generation of β-amyloid [24]. Here, BACE1 is linked to Alzheimer disease.