As cytotoxic effects of Rhiz were most pronounced in AR-V7-positive cells, we assume that apart from inducing apoptosis, inhibiting pro-survival autophagy and blocking potassium channels, the downregulation of AR-V7 and AR-target genes substantially contributes to Rhiz ability to inhibit prostate cancer cell growth and proliferation. The gene discussed is AR; the disease is Familial prostate cancer.