For subgroup analyses of the age, family history and aggressive, all results showed a significant association between HOXB13 G84E mutation and PCa susceptibility (Early-onset: OR = 2.09, 95% CI: 2.24–3.75; Late-onset: OR = 1.71, 95% CI: 1.38–2.13; with family history: OR = 2.60, 95% CI: 2.19–3.10; without family history: OR = 1.71, 95% CI: 1.51–1.93; More-aggressive: OR = 2.38, 95% CI: 1.84–3.08; Less-aggressive: OR = 2.19, 95% CI: 1.66–2.90) (Figure 5). This evidence concerns the gene HOXB13 and posterior cortical atrophy.