Of interest, the expression of TRPV1 was upregulated at protein as well as mRNA levels in all MM cell lines and primary MM cells tested at pH6.8 compared to those at pH7.4, which was abolished by addition of the PI3K inhibitor LY294002 as well as an Akt inhibitor (Figures 2A and 2B). Here, AKT1 is linked to Miyoshi myopathy.