Because TRPV1 is among major pH sensors expressed in cancer cells [30–33], we first examined the effects of an antagonist and agonist of TRPV1 and found the critical role of TRPV1 in acid-induced activation of the PI3K/Akt pathway in MM cells (Figure 1B and 1C). This evidence concerns the gene TRPV1 and Miyoshi myopathy.