Radiation dose (p=0.041), yc T stage (p=0.002), yc N stage (p=0.002), ycTNM stage (p=0.001), tumor differentiation (p=0.001), median interval from completion of CRT to surgery (p=0.007) and post-CRT CEA level (p=0.011) were significantly different between the two groups. Here, CEACAM5 is linked to neoplasm.