In contrast to the in vivo colitis model where the major keratins were downregulated, HT-29 cells treated with 1000 ng/mL LPS exhibited upregulated K8 and K19 protein levels 48 h after LPS-treatment, as shown by Western blot (Figure 6A,B) and confocal analyses (Figure 6C). The gene discussed is KRT8; the disease is colitis.