Interestingly, plasma eotaxin was significantly elevated in HO-1−/−apoE−/− than HO-1+/+apoE−/− mice at 4 weeks (758±121 vs. 364±83 pg/mL, respectively) (Figure 8J), suggesting eotaxin might be produced at a later stage during AAA progression. This evidence concerns the gene APOE and triple-A syndrome.