The most frequently rearranged member of this family is the Ets Related Gene (ERG), which is overexpressed through gene fusion with the 5′ untranslated region of the gene encoding Transmembrane protease, serine 2 (TMPRSS2) in ∼40% of prostate tumors [2, 3]. The gene discussed is TMPRSS2; the disease is prostate neoplasm.