ISG15 and neoplasm: In a microarray analysis of gene expression in tumor samples from patients with diffuse-type gastric cancer, Jinawath et al. [63] reported that ISG15 (formerly G1P2) expression was upregulated in more than 50% of the tumors examined, compared with that in noncancerous gastric mucosa, ranking as the 32nd most highly expressed transcript among the differentially expressed genes identified.