ISG15 and hepatocellular carcinoma: In a study of HCV-induced HCC, Konishi et al. [155] found that single nucleotide polymorphisms (SNPs) of IFN-3 (formerly IL-28B) were associated with ISG15 expression in HCV-induced HCC tumors in humans, which indicates that future investigations of ISG15 as a prognostic biomarker in HCC patients should examine the IFN-λ3 genotype of patients to consider possible genetic influences on the correlation between ISG15 and HCC.