In the non-small-cell human lung carcinoma cell line, H1299, Jeon et al. showed that doxirubicin treatment reduces tumor cell proliferation via UBA7-mediated cleavage of ΔNp63α, and that ISG15 depletion inhibited the antitumor effects of doxirubicin [112]. The gene discussed is ISG15; the disease is neoplasm.