In another recent study, Hou et al. [153] found that the level of the ISG, DEXD/H-box helicase 58 (DDX58, formerly RIG-I), was significantly lower in human HCC tumor cells than that in noncancerous hepatocytes, and that patients with low DDX58 expression had shorter survival and poorer responses to IFN-α therapy. The gene discussed is IFNA1; the disease is hepatocellular carcinoma.