In addition, cell culture studies have implicated epigenetic silencing by the DNA methylation of IFN-responsive genes, including STAT1, TNF receptor superfamily member 10a (TNFRSF10A, formerly TRAIL-R1), IRF-7, and death associated protein kinase (DAPK), in the downregulation of IFN signaling in cervical cancer [125], Li-Fraumeni syndrome [126], colon cancer [127], renal carcinoma [128], melanoma [128], and lymphocytic leukemia [129]. Here, IFNA1 is linked to Li-Fraumeni syndrome.