Interestingly, late-stage breast cancers, including triple-negative breast cancers (TNBCs), become insensitive to the tumor suppressing activities of TGF-β, and instead readily exhibit epithelial-mesenchymal transition (EMT), invasive, and metastatic phenotypes in response to TGF-β [22]. This evidence concerns the gene TGFB1 and triple-negative breast carcinoma.