Moreover, there was also significant overlap of the differentially expressed genes in the carfilzomib-resistant MM cells and genes that were downregulated in human lymphoblastoid cells after sulforaphane treatment — LP-1/Cfz cells (72 out of 896 probe sets; P < 10−20) and KMS-11/Cfz cells (68 out of 887 probe sets; P < 10−20) — which may represent indirect Nrf2 targets (see Table S2 for the probe set lists). This evidence concerns the gene NFE2L2 and Miyoshi myopathy.