EGFR and hepatocellular carcinoma: Consequently, many GFRs, including EGFR, vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), c-mesenchymal-epithelial transition factor-1 (c-Met), and fibroblast growth factor receptor (FGFR), have been shown to be upregulated in HCC at the level of protein and gene expression [57].