Very recent results provided evidence that ionizing radiation specifically induces c-MYC amplification; in fact, high-level c-MYC amplification has been found in primary mammary epithelial cells following radiation doses between 2 and 4 Gy and elevated c-MYC amplification was more common in human breast cancer which developed after radiotherapy compared with breast cancer without previous radiation exposure [30]. This evidence concerns the gene MYC and breast cancer.