MSH5 and Fanconi anemia: In particular Brip1 gene, acting in the Fanconi anemia pathway, and Xpc, belonging to the NER pathway, were found up-regulated in Ptch1+/− GCPs (1.23-fold and 1.2-fold compared to WT, respectively) while 5 mRNAs were found down-regulated more than 20%, i.e., Rad51d (0.31; part of the DSB repair pathway), Mlh1 and Msh5 (0.40 and 0.78, respectively; related to the Mismatch Repair pathway), and Neil2 and Parp3 (0.54 and 0.78, respectively; related to the Base Excision Repair pathway).