Furthermore, the hypothesis that plasma HO-1 is the results of an active mechanism of secretion and not the consequence of cell necrosis is supported by previous work showing that HO-1 is increased in patients with acute myocardial infarction independently of cell necrosis biomarkers (i.e troponin and creatine phosphokinase) [25]. The gene discussed is HMOX1; the disease is myocardial infarction.