Finally, we assessed apoptosis at distance of tumor as already reported for murine CMV infection.22 We found caspase-3 and caspase-9 activations especially in lung tissue of mice injected subcutaneously with HCMV-infected HepG2 cells but not from the control groups using western blotting (Figure 7). This evidence concerns the gene CASP3 and cytomegalovirus infection.