MAPK14 and neoplasm: p38, a subgroup of the MAPKs, was firstly described as a transducer of the response to environmental stress conditions and as a critical mediator of inflammatory cytokines, but many different non-stress stimuli can also activate p38 MAPK signaling, leading to the regulation of multiple cellular processes, including senescence, apoptosis, cell-cycle arrest, regulation of RNA splicing, tumor development or differentiation of various cell types such as neurons, adipocytes, cardiomyocytes and myoblasts (reviewed in Cuenda and Rousseau, 2007; Igea and Nebreda, 2015).