However, according to Decipher, no cases of SOD-1 deletions (chr21:31659622–31668930, hg38) have been associated with tremor until now and the unique family with SOD-1 null mutation manifested an atypical form of familial amyotrophic lateral sclerosis [10]. Here, LGR5 is linked to familial amyotrophic lateral sclerosis.