In one study of 150 patients with CNC, a higher frequency of PDE11A variants was observed when compared with healthy controls (25.3 versus 6.8%, P < 0.0001), particularly in men (30.8 versus 13%, P = 0.025, PPNAD subgroup) (16). The gene discussed is PDE11A; the disease is primary pigmented nodular adrenocortical disease.