PDE11A and adrenal cortex carcinoma: Libé et al. (27) examined the role of the PDE11A in a large cohort of ACT, and found an inactivating mutation (p.R307*) in one ACC, with a significant difference between ACC and controls for a polymorphism in exon 6 (p.E421E; OR, 2.1; P = 0.03) (27).