In some forms of thrombotic microangiopathy (e.g., preeclampsia or sirolimus-induced thrombotic microangiopathy), which share several morphological features with malignant hypertension, the expression or function of endothelial growth factors, like vascular endothelial growth factor (VEGF), is impaired (Levine et al., 2004; Sartelet et al., 2005). The gene discussed is VEGFA; the disease is preeclampsia.