WDR13 and depressive symptom measurement: The changes observed at 10 months in Wdr13−/0 mice might have resulted from accumulating molecular changes in the brain due to the absence of Wdr13. Since de-regulation of glutamate can lead to changes in memory (McEntee and Crook, 1993; Gecz, 2010), anxiety (Bergink et al., 2004), depression (Sanacora et al., 2012), etc., it would be interesting to study the behavioral phenotype of Wdr13−/0 mice at 10 months of age.