There are some technical issues relating to the interpretation of these estimates with a binary outcome and a logistic regression model due to the non‐collapsibility of odds ratios (they approximate a population‐averaged log odds ratio per unit change in the distribution of the risk factor Burgess & CHD CRP Genetics Collaboration, 2013), but each is a consistent estimator under the null, and each provides a valid test of the null hypothesis of no causal effect (Vansteelandt, Bowden, Babanezhad, & Goetghebeur, 2011). The gene discussed is CRP; the disease is coronary artery disorder.