Mice lacking the DNA methylation reader MeCP2 are attenuated in their liver fibrosis and mecp2-deficient HSC show reduced levels of fibrogenic markers collagen 1, TIMP-1 and aSMA.74 PPARγ expression must be silenced for HSC to activate and acquire their myofibroblast phenotype and this is achieved by two concurrent epigenetic mechanisms. Here, MECP2 is linked to Hepatic fibrosis.