EPCAM and hepatocellular carcinoma: Combined with transcriptomics, the study identified mRNA signatures enriched with progenitor cell features such as epithelial cell adhesion molecule (EpCAM) and S2 (p=0.009 and p=0.006, respectively) in the DNA methylation MI high group.36 The landscape of aberrant methylation in human HCC displayed general hypomethylation compared with normal liver, mainly located in the intergenic (39.9%) and body regions (34.5%), whereas hypermethylated probes were generally in promoter areas (50.5%).