VLDLR and early-onset autosomal dominant Alzheimer disease: Furthermore, α-Mangostin encapsulated poly(ethylene glycol)-poly(l-lactide) (PEG-PLA) nanoparticles ameliorates Alzheimer’s disease neuropathology by elevating low density lipoprotein receptor (LDLR) expression in microglia and liver cells and accelerating amyloid-beta clearance47.