Aberrant activation of Shh signaling pathway has been implicated in several cancers such as pancreatic cancer, prostate, glioblastoma, squamous cell carcinoma, basal cell carcinoma, medulloblastoma, prostate cancer, colon cancer, rhabdomyosarcoma and breast cancer31, 36, 37, 38, 39, 40. This evidence concerns the gene SHH and familial pancreatic carcinoma.