APOC3 and hepatocellular carcinoma: In order to further confirm the effects of miR-4271 on endogenous APOC3 expression, we sequenced nine of the human hepatoma cell lines (including HepG2, HuH-7, Hep3B, LM3, HLE, HLF, 97L, PLC, L02, etc.)and HepG2 was identified to be TT genotype, while 97L was identified to be GG genotype (Supplementary Figure 3).