However, unlike NOX4, in most contexts NOX2 was also shown to aggravate HF: NOX-2 drives CM hypertrophy in response to stimulation with angiotensin II, noradrenaline, endothelin-1, aldosterone and mechanical stress after aortic constriction through adapter proteins and transcription factors (including Ras/Erk, ASK-1 and NF-κB)22. This evidence concerns the gene CYBB and hydrops fetalis.