In addition, our experiments using phosphorylation site-specific antibodies showed that ATP-induced synaptic depression from hippocampal slices10 is associated with a fast and reversible dephosphorylation of GluA1 at the CaMKII phosphorylation site S567 without change in the phosphorylation levels of S845 or S831. Here, GRIA1 is linked to major depressive disorder.