The intracellular pathogen decreases efp mRNA levels during the course of infection, which selectively stimulates expression of the virulence mgtC gene by inducing ribosome stalling at the consecutive proline codons of the mgtP open reading frame in the mgtCBR leader RNA, thus allowing the formation of a stem-loop structure promoting transcription of the mgtC gene (61). The gene discussed is TRIM25; the disease is infection.