INS and major depressive disorder: Additionally, a moderate reduction of 5-HT1A binding in people with depression relative to healthy controls was detected in HIP: −0.29 (95 % CI −0.51, −0.07), CAN: −0.57 (95 % CI −1.24, −0.09), OCC: −0.35 (95 % CI −0.96, −0.04), RN: −0.60 (95 % CI −1.17, −0.04) and INS: −0.79 (95 % CI −0.54, −0.05) (Fig. 2).