The genes within 2 Mb of the signal, include RP11-81H3.2, CAPS2, GLIPR1, GLIPR1L1, GRLPR1L2, and KRR1, none of which is an obvious candidate gene for involvement in obesity or T2D. This evidence concerns the gene GLIPR1L1 and obesity due to melanocortin 4 receptor deficiency.