In recent years, serum tumor markers, including neuron-specific enolase (NSE) [7-9], carcinoembryonic antigen (CEA) [10, 11], cytokeratin-19 fragments (Cyfra21-1) [12] and squamous cell carcinoma antigen (SCCA) [13] have been extensively investigated, and considered potentially predictive and prognostic in non-small cell lung cancer. Here, ENO2 is linked to neoplasm.