ENO2 and neoplasm: By univariate analysis, advanced clinical stage (P = 0.009 for DFS; P = 0.046 for OS), larger tumor size (P = 0.001 for DFS; P = 0.002 for OS), regional lymph node metastasis (P = 0.024 for DFS; P = 0.030 for OS), higher NSE level (P = 0.002 for DFS; P < 0.001 for OS), and higher TMI (P = 0.009 for OS) were significantly correlated with a worse prognosis (Table 3).