NSCLC with neuroendocrine properties was previously reported to be chemosensitive but was associated with poorer outcomes similar to small cell lung cancer.[29] In another study, elevated serum NSE predicted NSCLC resistance to EGFR-TKIs and it was speculated that transition to small cell lung cancer occurred after acquisition of EGFR-TKI resistance [9]. The gene discussed is ENO2; the disease is non-small cell lung carcinoma.