Three out of five relapsed xenografts showed dysregulation of epigenetic modifiers: ALL-27 showed up-regulation of SETD7 in relapse; ALL-42 showed down-regulation of KDM5B; and ALL-46 showed the most changes, with two epigenetic modifiers up-regulated (HDAC9, SMARCD3) and three down-regulated (KDM5B, HDAC7, FBXO10). This evidence concerns the gene HDAC7 and acute lymphoblastic leukemia.