Other studies showed that body mass index (BMI), preoperative prostate-specific antigen (PSA) level, percentage of positive biopsies, pathological T stage, lymph node metastasis, positive surgical margin, extracapsular extension, and seminal vesicle invasion were major risk factors in developing prostate cancer biochemical recurrence [19–22]. This evidence concerns the gene KLK3 and metastatic malignant neoplasm in the lymph nodes.