H2BC21 and hepatocellular carcinoma: To determine whether histones induce HCC cell migration and invasion, we treated Huh7 (a human HCC cell line) and Hepa1-6 (a mouse HCC cell line) with highly purified histones including H1, H2A, H2B, H3, and H4 at 10-50 μg/ml as previously reported [18].