Class switching to the allergy-associated IgE was unaffected by the loss of ORMDL3 (Fig 2, E), although there was a modest decrease in the levels of Alternaria-specific IgE (0.78OD vs 0.61OD) (Fig 2, F) in Ormdl3 KO miceMer. The gene discussed is IGHE; the disease is allergic disease.