The intra-articular injection of p97 siRNAs, compared to control siRNAs, significantly suppressed arthritis scores (Figure 5C, 5D), grades of bone erosion (Figure 5E, 5F) and cartilage destruction (Figure 5G, 5H), and the Hsp47-positive fractional area in synovial tissues (Figure 5I, 5J) of ankle joints. The gene discussed is SERPINH1; the disease is arthritic joint disease.