Increasing corticosterone levels could induce depression-like behaviors and decrease hippocampal neurogenesis.44, 53, 54 Our results showed that knockdown of Wnt2 or Wnt3 increased serum corticosterone and ACTH levels, which suggested that corticosterone and ACTH might be involved in Wnt-related depression-like behaviors. The gene discussed is POMC; the disease is major depressive disorder.