Previous studies have shown that Wnt/β-catenin signaling is involved in depression- but not anxiety-like behaviors by using β-catenin overexpressing transgenic mice or conditional β-catenin knockout mice.16, 17 Our data provided several new insights into the roles of Wnt2 and Wnt3 in CRS-induced depression-like behaviors. This evidence concerns the gene WNT3 and major depressive disorder.