The results revealed that there were no significant changes of Wnt2/3 mRNA (Supplementary Figure S3; Wnt2, t18=0.019, P=0.985; Wnt3, t18=−0.468, P=0.645, two-tailed t-test), suggesting that the decreased Wnt2/3 gene expression was specific to CRS. The gene discussed is WNT3; the disease is congenital rubella syndrome.