WNT2 and congenital rubella syndrome: We found that overexpression of Wnt2 or Wnt3 had no effect on serum corticosterone or ACTH levels under basal condition, whereas overexpression could reverse the CRS-induced increase in serum levels of corticosterone and ACTH (Figure 3e; CRS-Lenti-Wnt2, P<0.001; CRS-Lenti-Wnt3, P<0.001; Figure 3f; CRS-Lenti-Wnt2, P<0.001; CRS-Lenti-Wnt3, P=0.001).