Under stress condition, overexpression of Wnt2 or Wnt3 could rescue the CRS-induced decreases in p-GSK3β (Ser9) (CRS-Lenti-Wnt2, P=0.013; CRS-Lenti-Wnt3, P=0.005) and nuclear β-catenin (CRS-Lenti-Wnt2, P<0.001; CRS-Lenti-Wnt3, P<0.001), suggesting that Wnt2 and Wnt3 rescued the CRS-induced Wnt/β-catenin signaling impairment. Here, WNT3 is linked to congenital rubella syndrome.