We found that two weeks of i.p. injections of fluoxetine significantly reversed the CRS-induced decrease in Wnt2 and Wnt3 levels compared with CRS+SAL group (Figure 5a; Wnt2: F6,45=29.602, P<0.001, one-way ANOVA; post hoc test, P=0.002; Wnt3: F6,45=30.120, P<0.001, one-way ANOVA; post hoc test, P<0.001), suggesting that Wnt2 and Wnt3 may be involved in the fluoxetine effect. This evidence concerns the gene WNT2 and congenital rubella syndrome.