For example, miR-200a, miR-429 and miR-141 were shown to play important roles in neurogenesis, epithelial-to-mesenchymal transition and Notch signaling [73, 75–84], miR-214 was found to be overexpressed in fetal sclera versus adult sclera and shown to play important role in brain and retina development and function [36, 85–89], miR-18b, miR-21, miR-101a, miR-200a and miR-429 were found to be involved in stem cell function and differentiation [90–100], miR-1306 negatively regulated Alzheimer’s disease gene ADAM10 [101]. The gene discussed is ADAM10; the disease is early-onset autosomal dominant Alzheimer disease.