Based on typical glaucomatous arcuate deficits51, 52 and RNFL defects8, 11, and evidence that regional visual field deficits can be mapped to sectoral optic disc abnormalities in glaucoma7, 9, 53, 54, we introduce a quadrant field stimulation paradigm using optimised pupillometry protocols39 in order to differentiate melanopsin function in glaucoma suspects and manifest glaucoma at different severity stages from healthy eyes by measuring the PLR and PIPR. The gene discussed is OPN4; the disease is glaucoma.