Despite a large number of cross-sectional studies dating back to the 1990s (Ganguli et al., 1994, Maes et al., 1994) as well as meta-analyses (Miller et al., 2011, Miller et al., 2013, Potvin et al., 2008, Upthegrove et al., 2014) reporting increased CRP and inflammatory cytokines in acutely unwell patients with schizophrenia, longitudinal studies are scarce (Gardner et al., 2013, Khandaker et al., 2014a, Wium-Andersen et al., 2014). This evidence concerns the gene CRP and schizophrenia.