Although Matsunaga et al. have reported that the abrogation of CAM-DR in AML cells is promoted through the downregulation of the anti-apoptotic protein Bcl-2, we found that the FNIII14 peptide enhanced expression and activation of the pro-apoptotic BH3-only Bcl-2 family protein, Bim, in solid tumor cells. The gene discussed is BCL2; the disease is acute myeloid leukemia.