In the present study, we found that the NOD1 agonist Tri-DAP-stimulated IL-6 and TNF-α release in both blood samples and PBMCs collected from pediatric CHD patients was markedly reduced immediately after CPB, whereas the NOD2 agonist MDP-stimulated IL-6 release in blood samples and MDP-stimulated TNF-α release in PBMCs were also substantially decreased immediately after CPB, indicating that CPB suppresses NOD signaling-mediated inflammatory response in pediatric CHD patients. This evidence concerns the gene NOD2 and coronary artery disorder.