Moreover, a strong down-regulation of NOD1 protein expression was found in PBMCs of pediatric CHD patients at day 1 post-CPB (Fig 4), whereas substantially reduced expression of NOD2 protein was also observed immediately post-CPB and at day 1 post-CPB in PBMCs of pediatric CHD patients (Fig 4). This evidence concerns the gene NOD2 and coronary artery disorder.