NOD2 and coronary artery disorder: NOD1 mRNA expression in pediatric CHD patients was significantly down-regulated at day 1 post-CPB compared with the preoperative level (p<0.01) and returned to preoperative levels from day 3 post CPB (Fig 3A), whereas NOD2 mRNA expression was reduced immediately post-CPB, but was not significantly different compared with the preoperative level (Fig 3B).