Analysis of the association between Ezrin and p130cas expression in effusions and clinicopathologic parameters showed overexpression of p-ERM protein in peritoneal compared to pleural effusions (p = 0.024), higher Ezrin protein levels in effusions from patients who had suboptimal debulking (p = 0.017) and overexpression of p130cas protein in post-chemotherapy effusions compared to effusions tapped pre-chemotherapy at diagnosis (p = 0.032). The gene discussed is EZR; the disease is Pleural effusion.