ATRAID and hyperinsulinemic hypoglycemia, familial, 4: In msa1-1 we identified several differentially methylated genes which are known to be responsive to S deficiency (S7 Table), including two high-affinity sulphate transporter genes SULTR1;1 and SULTR1;2, and the S assimilation gene APR3 (Fig 6C–6E) which are hypo-methylated in msa1-1 compared to WT.