In contrast to these findings, morpho-logical characterization of the ocular phenotype of aged Pparβ/δ−/− mice revealed the exacerbation and development of several features of the early dry AMD phenotype including continuous sub-RPE deposits, increased RPE autofluorescence, Bruch's membrane thickening, RPE pigmentary changes and disorganized basal infoldings. The gene discussed is PPARD; the disease is dry age related macular degeneration.